3 There is an increasing trend of intentionally or unintentionally using non-insulin-based treatment for managing T2DM during pregnancy, with a progressive interest towards glucagon-like peptide-1 receptor agonists (GLP-1RA) in this context. 4 Pre-pregnancy effectiveness The use of GLP-1RA in a pre-pregnancy setting is relevant in the context of managing obesity, polycystic ovarian syndrome (PCOS) or control of hyperglycaemia in T2DM.
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GLP-1 receptor agonist therapy and pregnancy: Evolving and emerging evidence.
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