Antidepressants in the treatment of bipolar depression: commentary.

Int J Neuropsychopharmacol · 2025 · PMC11929952 · PMID 39964358

Europe PMC DOI

hedged sentence

0.0001

closest p · 0.0× alpha

0.0001

boldest claim

The sentences

highly significantP < .0001actually significant

6 of 12 monotherapy trials found response rates of 393/803 (48.9% [45.4–52.5] with ADs vs 419/1092 (38.4% [35.5–41.3]) with placebo, a moderate (1.27-fold) but statistically highly significant difference of 1.27-fold (χ 2 = 21.1; meta-analytic pooled risk ratio = 1.32 [1.07–1.62]; both P < .0001).

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.