The results showed that the co-localization of lysosomes and mitochondria, autophagic vesicles and mitochondria showed a decreasing trend after the addition of TBHP, which indicated that the occurrence of ferroptosis in chondrocytes was accompanied by a decrease in mitophagy ( Fig. 5 g).
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JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy.
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