Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism.

As a proof of concept study, we analysed the MMP11 plasma levels in the NMRI (nu/nu) tumor-free healthy mice and in the NMRI (nu/nu) mice bearing subcutaneous head and neck squamous cell carcinoma (HNSCC) xenograft tumors and found a statistical trend toward increased MMP11 levels in the tumor-bearing mice (Figure S6D).

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