Lack of support for the association between GAD2 polymorphisms and severe human obesity.

Moreover, it must be pointed out that the marginally significant association ( p = 0.04) they observed between the −243 G allele and class III obesity was observed in only one of their two groups of participants, and did not reach nominal significance in their family-based analysis ( p = 0.06).

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However, we observed marked and highly significant differences in allele frequency for the −243 A>G SNP between Caucasians and populations of West African origin represented by samples collected in the US or in France.

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