This finding can justify the highly significant differences between 2D Doxil® treated cells, which lack the connectivity of ECM found in the 3D model and work as a barrier for Doxil ® particles to diffuse and reach the spheroids [ 36 ]. 4.
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In vitro cellular interaction of drug-loaded liposomes with 2D and 3D cell culture of U87-MG cell line.
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