Consumption of dopamine receptor 1 agonist SKF-38393 reduces constant-light-induced hyperactivity, depression-like, and anxiety-like behaviors in a sex specific manner in C57BL/6J mice.

While we cannot definitely state that female mice exhibit increased DA preference compared to males because water consumption was also increased, other studies investigating drugs of abuse, including alcohol ( Gelineau et al., 2017 ; Sneddon et al., 2019 ), cocaine ( Russo et al., 2003 ; Roth and Carroll, 2004 ), and opiates ( Hammerslag et al., 2021 ), illustrate an overall trend of increased drug intake in both binge-like and chronic consumption patterns in female rodents compared to males.

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