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Ecological determinants driving orthohantavirus prevalence in small mammals of Europe: a systematic review.

One Health Outlook · 2025 · PMC11938672 · PMID 40134030

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In the Americas, sigmodontinae -borne hantaviruses cause the most severe cases of hantavirus cardiopulmonary syndrome (HCPS), with fatality rates reaching 60% [ 42 ]. In Europe, human hantavirus infection is a concerning issue aggravated by the lack of available and effective vaccines, an increasing trend in the number of reported human cases, and an increase in the endemicity of natural host species [ 2 , 3 , 17 , 23 ].

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