Demographic and regional mortality trends in dilated cardiomyopathy in the United States; 1999-2020.

From 1999 to 2005, AAMR in males showed a decreasing trend, with an APC of −0.69 (95% CI: −2.81 to 3.43), after which there was a steeper decrease in AAMR (APC: −5.98; 95% CI: −10.47 to −5.12) until 2016, preceded by an increase in trend from 2016 to 2020 (APC: 0.81; 95% CI: −3.59 to 10.26).

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Initially, we observed a drop in mortality trend from 1999 to 2002 (APC: −5.10; 95% CI: −12.09 to 0.51), preceded by an increasing trend from 2002 to 2005 (APC: 6.32; 95% CI: −6.20 to 10.14), followed by a decline from 2005 to 2014 (APC: −6.14; 95% CI: −10.75 to −4.17) and a slower rate of decline from 2014 to 2020 (APC: −1.52; 95% CI: −4.18 to 5.85) ( Supplemental Table S4 , Figure 3 ).

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