A highly significant enrichment of the gene signature DC1 was identified in the ductal cells of T1D donors; as these cells lack expression of co-stimulatory factors CD80 and CD86, this may suggest an attempted decoy role for DC1 cells (to deactivate CD4 + T-cells) in T1D [ 19 ].
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Tissue Resident and Infiltrating Immune Cells: Their Influence on the Demise of Beta Cells in Type 1 Diabetes.
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