Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling.

In contrast, highly significant effects of exposure duration were observed for all four molecules, and ethanol × exposure duration interactive effects were detected for mTOR and RPS6 ( p < 0.0001) ( Table 6 ).

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Results General Characteristics: Two-way ANOVA tests demonstrated significant ethanol effects on blood alcohol concentration (BAC), body weight, and brain weight, significant exposure duration effects on body weight, brain weight, and liver weight, and a statistical trend-wise effect of exposure duration on BAC ( Table 1 ).

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