Using Integrated Network Pharmacology and Metabolomics to Reveal the Mechanisms of the Combined Intervention of Ligustrazine and Sinomenine in CCI-Induced Neuropathic Pain Rats.

Compared to the model group, the incapacitance score in the LGZ+SIN, LGZ, and SIN groups showed an increasing trend following treatment, with more pronounced improvements on the second and third days of administration.

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Over the 3-day treatment period, the cold pain sensitivity scores in the LGZ+SIN and SIN groups showed a decreasing trend compared to the model group.

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