Folic Acid Alleviates Hydrogen Peroxide-Induced Oxidative Stress in Bovine Placental Trophoblast Cells by Regulating the NRF2/mTOR Signaling Pathway.

Effect of Combined Treatment with FA, H 2 O 2 , and ML385 on the Abundance of Cellular Pathway Proteins The protein abundance of mTOR in cells showed a decreasing trend, while the NRF2 in the nucleus was increased ( p < 0.05, Figure 15 ). 3.

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After adding FA pretreatment, the FA+ H 2 O 2 group exhibited a decrease in the protein abundance of nuclear NRF2 and an increasing trend in mTOR protein abundance ( Figure 9 ). 2.9.

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