Association of Endothelial Nitric Oxide Synthase Polymorphisms with Clinical Severity in Patients with COVID-19.

However, there was a notable trend toward significance at the margin of the threshold because the 4b/4b genotype ( p = 0.07) and the 4b allele ( p = 0.06) were represented at a higher frequency in patients with severe COVID-19 than in those with mild disease ( Table 5 ).

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However, the subgroup analysis showed a notable trend for the 4b/4a allele distribution between Groups 1 and 2.

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We found a trend in the association of disease severity and patient genotypes at the margin of statistical significance level in a subgroup of younger patients (<50 years of age) without COPD (see Table 5 ).

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