Improved MRI detection of inflammation-induced changes in bone marrow microstructure in mice: a machine learning-enhanced T2 distribution analysis.

Discussion This study demonstrates that T2-weighted imaging, scalar T2 mapping, and T2 distribution analysis are effective in detecting inflammation-induced changes in the femoral bone marrow in mice, particularly within the metaphysis, a critical site for hematopoietic activityT2-weighted imaging and scalar T2 mapping showed borderline significant decreases in SNR and T2 relaxation times, correlating with inflammation, while MIML-based T2 distribution analysis revealed more significant reductions in the first peak mean with increasing levels of inflammation.

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