Comparison of the Human Plasma Peptides from the Fit of Fragmentation Spectra versus Accurate Monoisotopic Precursor Mass.

As expected, the precursor mass [M + H] + obtained by the OIT exhibited sharp delta mass peaks at −3, −2, −1, 0, +1, +2, +3, +4, and +5 Da due to naturally occurring heavy isotopes and hydrogen rearrangements. The collection of peptides and proteins identified by OIT and LIT was in qualitative and quantitative agreement with one another, with 99.9% overlap on 2726 protein gene symbols from human plasma and a highly significant relationship by regression analysis.

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