When normalized by the fold change of mutant-stimulated versus wild-type peptide stimulation, significantly higher fold changes were observed for Neo1 and Neo3 in mutant mRNA-treated mice compared to wild-type mRNA-treated mice, with only an increasing trend noted for Neo4 (Fig. 6 B).
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Neoantigen-based mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model.
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