Empirical calibration of a simulation model of opioid use disorder.

PLoS One · 2025 · PMC11949371 · PMID 40146669

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an increasing trendno p-value reported

When calibrating to the yearly total OUD population, we used the 2015 total OUD counts and constrained our calibration to only select parameters that resulted in an increasing trend in OUD from 2013 to 2015.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.