A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome.

J Immunol · 2025 · PMC11952872 · PMID 40101747

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0.0600

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close to significanceP = 0.06so close (0.05 < p ≤ 0.1)

42 When we used qPCR to measure the abundance of the corresponding transcripts in PBMC from MIS-C patients, we observed that the baseline (ie unstimulated) mRNA levels of SOCS1, TOLLIP, and SHIP1 were higher in the MIS-C patient cells relative to healthy controls (the comparison for SARM1 was close to significance, P = 0.06) ( Fig. 2A for heatmap and Fig. 2B for boxplots).

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