Barely Significant
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Metformin use and risk of total joint replacement in patients with diabetes: a longitudinal cohort study of Alberta's Tomorrow Project.

BMC Musculoskelet Disord · 2025 · PMC11956490 · PMID 40165152

Europe PMCDOI
1
hedged sentence
0.0530
closest p · 1.1× alpha
0.0530
boldest claim

The sentences

borderline significantp -value = 0.053so close (0.05 < p ≤ 0.1)
Nevertheless, a borderline significant difference ( p -value = 0.053 for testing interaction) was observed in the association between metformin use and total joint replacement for patients with concurrent use of pain drugs (HR = 1.24, 95% CI = 0.63–2.45) vs. without (HR = 0.56, 95% CI = 0.36–0.89) (Supplementary Table S2 ).

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