Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer's disease.

3 A, B), 5×FAD mice revealed a decreasing trend of print areas (F (2, 54) = 1.231, P = 0.3002, F (2, 52) = 16.10, P < 0.0001, F (2, 52) = 9.051, P = 0.0004, F (2, 53) = 25.03, P < 0.0001, Fig. 3 C) and maximum intensity (F (2, 54) = 3.868, P = 0.0269, F (2, 53) = 9.775, P = 0.0002, F (3, 72) = 2.691, P = 0.05, F (2, 54) = 6.552, P = 0.0028, Fig. 3 D) of all paws with age, and the statistic difference between 3- and 9-m old ones was significant.

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