Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non-Small Cell Lung Cancer.

The prognostic value of MRD remained highly significant when accounting for guarantee-time bias (HR = 0.03; 95% CI, 0.016–0.056; P < 0.0001; Supplementary Table S2).

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Stratifying by disease stage revealed an interesting trend: The PPV of longitudinal MRD tended to increase with advancing stage, whereas the NPV showed a decreasing trend ( Fig. 2E ).

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