Activation of gut FXR improves the metabolism of bile acids, intestinal barrier, and microbiota under cholestatic condition caused by GCDCA in mice.

Microbiol Spectr · 2025 · PMC11960106 · PMID 39982108

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an increasing trendno p-value reported

Compared with GCDCA, GW4064 led to an increasing trend in total or primary BA levels in the gut ( Fig. 3D and E ), suggesting that GW4064 may increase the intestinal excretion of BAs.

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