Reactivating the phototransduction cascade with a mutation agnostic gene therapy preserves vision in rod-cone dystrophies.

scRNAseq revealed that there are no significant changes in Opn1sw , Gnat2 , Gnb3 , Pde6h , Gngt2 , Rcvrn , and Arr3 transcript levels in the rd10 retinas compared to the similarly aged wild-type retinas; a decreasing trend can be observed in rd10 retinas ( Figure 1 ).

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