Applying our computational analysis pipeline to DNA-FISH intensity and BRD4 signal at this locus yielded a highly significant correlation at Day 1 of transdifferentiation (Fig. 2G ), as well as an enrichment of BRD4 signals in IRF8 DNA-FISH centers compared to randomly allocated spots (Fig. 2H ).
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Synergistic and antagonistic activities of IRF8 and FOS enhancer pairs during an immune-cell fate switch.
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