Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants.

Cancer Discov · 2025 · PMC11962394 · PMID 39786370

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.1100

boldest claim

The sentences

borderline significantP = 0.057so close (0.05 < p ≤ 0.1)

Among patients who received allogeneic HCTs at Vanderbilt, the use of nonselective β-blockers was again associated with a borderline significant reduction in OS (median 25 vs. 56 months, P = 0.057; Fig. 7G ): 1-year OS was 68% versus 76% and 2-year OS was 54% versus 65%.

also in 11,409 other papers

a nonsignificant trendP = 0.11not close (p > 0.1)

Patients on nonselective β-blockers exhibited a nonsignificant trend toward an inverse correlation between cell dose and time to neutrophil engraftment ( R 2 = 0.086, P = 0.11; Fig. 4D ), but not patients who were not on a nonselective β-blocker ( R 2 = 0.00068, P = 0.55; Fig. 4E ).

also in 5,406 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.