Discovery of novel azole derivatives with benzanilide-containing hydrophobic side chains for the treatment of drug-resistant fungal infections.

Introduction With the increasing number of human immunodeficiency disease patients and the use of anti-tumor chemotherapy drugs, the incidence of fungal infection has shown an increasing trend year by year and the invasive infection has become one of the important causes of clinical death. 1–4 At present, antifungal drugs are mainly composed of polyenes ( e.g. , amphotericin B), echinococcus ( e.g. , caspofungin), allylamines ( e.g. , terbinafine) and azole drugs ( Fig. 1 ). 5 Azole drugs such as imidazole ( e.g. , miconazole, MCZ), triazole ( e.g. , fluconazole, FLC) and tetrazoles ( e.g. , oteseconazole) are widely used in clinic because of their excellent therapeutic effect.

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