Barely Significant
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Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.

Eur J Endocrinol · 2025 · PMC11962913 · PMID 40070360

Europe PMCDOI
1
hedged sentence
0.0620
closest p · 1.2× alpha
0.0620
boldest claim

The sentences

borderline significantP = .062so close (0.05 < p ≤ 0.1)
15 , 17 , 45 By this method, R304Q displays a borderline significant reduced interaction compared with wild-type AIP ( P = .062). 45 In a different study, the expression of phosphodiesterase 4A4 (PDE4A4) and phosphodiesterase 4A8 (PDE4A8) were analysed in human somatotrophinomas with confocal microscopy and immunofluorescence. 32 AIP mut-positive PitNETs were associated with low levels of PDE4A4 and PDE4A8 expression.

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