LAAC was associated with a numerical trend towards lower risk of hemorrhagic stroke when compared with DOACs (OR, 0.45 [95% CI, 0.17–1.22]) with no evidence of inconsistency between direct and indirect treatment comparisons ( P =0.927).
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Left Atrial Appendage Closure Compared With Oral Anticoagulants for Patients With Atrial Fibrillation: A Systematic Review and Network Meta-Analysis.
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