Metabolic modelling reveals the aging-associated decline of host-microbiome metabolic interactions in mice.

Nat Microbiol · 2025 · PMC11964932 · PMID 40140706

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Comparing genes responsive to microbial colonization (comparison CONVR versus GF and CONVD versus GF; Supplementary Tables 2.8 – 2.12 ) and those associated with microbiome function, we found a highly significant overlap in colon and liver, but not in brain (Fig. 2d ).

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