Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition.

In the EUR GWAS for Aβ, we found that rs76490923 had a marginally significant association (beta = −0.1240, SE = 0.0404, p = 2.20 × 10 −3 ) with Aβ in EUR population. rs76490923 was associated with decreased Aβ levels and exhibited the same effect directionality (beta coefficient, −0.1240 [EUR] vs. −0.1661 [EAS]) as in our EAS GWAS results (Fig. 2 ).

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