Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice.

Front Pharmacol · 2025 · PMC11965660 · PMID 40183098

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highly significantp < 0.0001actually significant

Further, the IBC treatment at 5 μM and 10 μM concentrations showed a highly significant (p < 0.0001) reduction of speck formation in cells, in comparison to the cells induced with ATP, indicating reduced oligomerization ( Supplementary Figures S2E, F ).

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