Intriguingly, in subjects with high methanogen phenotype within these age groups, butyrate kinase ( K00929 ), the terminal enzyme in the butyrate kinase pathway responsible for synthesizing butyrate, exhibited statistically elevated levels (q < 0.01) and the gene coding for phosphate butyryltransferase ( K00634 ) displayed an increasing trend (though not reaching statistically significance), hinting at the potential significance of the butyrate kinase pathway in the elevated butyrate levels in these individuals (Fig. 4 A).
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Age-related dynamics of predominant methanogenic archaea in the human gut microbiome.
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