Trends of Azole-Resistant Aspergillus Fumigatus Susceptibility Over 12 Years from a German ECMM Excellence Center.

Here, comparing the GM MICs of VCZ against pre- and post-COVID isolated ARAFs with a TR 34 /L98H mutation, an increasing trend without statistical significance could be detected.

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In contrast, the Dutch surveillance network reported a decreasing trend in the mean VCZ MIC values amongst A. fumigatus isolates harbouring the TR 34 /L98H mutation from 8 mg/L in 2013 to 2 mg/L in 2018 and the resistance rates towards VCZ declined around 34% in this time [ 23 ].

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