Comparative efficacy and safety of transarterial chemoembolization combined with tyrosine kinase inhibitors and immune checkpoint inhibitors versus tyrosine kinase inhibitors and immune checkpoint inhibitors alone in advanced hepatocellular carcinoma: a systematic review and meta-analysis.

Notably, pain (any grade; RR = 3.94, P < 0.00001) and nausea/vomiting (any grade; RR = 2.28, P < 0.0001) were significantly more common in the TACE + TKIs + ICIs group, while decreased appetite and abnormal liver function showed higher heterogeneity (I 2 > 50%) and borderline significance ( P = 0.28 and P = 0.06, respectively).

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