Replenishing co-downregulated miR-100-5p and miR-125b-5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption.

Using Sylamer , there was highly significant enrichment for the seed complementary regions (SCRs) corresponding to the 1–8 nt seed region of both miR‐99a‐5p/miR‐100‐5p and miR‐125b‐5p in the most downregulated genes at d2 following combination mimic treatment, a timepoint at which the direct effects of miRNAs on mRNA transcripts are greatest [ 40 ], in both TCam2 and 1411H cells, shown in landscape plots (Fig. 3C ).

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