Similarly, when we sorted PD1 + and PD1 – CD8 + T cells from peripheral blood of patients with HIV and leukemia using flow cytometry, we observed a decreasing trend in 2-HG levels, particularly a decrease in L-2-HG, which aligns with our in vitro experimental results ( Figure 2C ).
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Immunometabolite L-2-HG promotes epigenetic modification of exhausted T cells and improves antitumor immunity.
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