Convergence of Cannabis and Psychosis on the Dopamine System.

There was also a set of voxels in the mediodorsal SN/VTA where neuromelanin-MRI signal was lower in participants with CUD, although this did not achieve significance (211 of 2060 SN/VTA voxels, corrected P =.15, permutation test) ( Figure 2 ).

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Unlike prior studies of untreated psychosis, 32 we did not see a higher neuromelanin-MRI signal in those with FES compared to healthy controls, but noted a numerical trend in the relevant voxels (eFigure 2 in Supplement 1 ). 27 Alongside the lack of power, it is possible that the limited effect of FES on neuromelanin-MRI signal is due to treatment effect.

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