Epigenetic age acceleration predicts subject-specific white matter degeneration in the human brain.

Aging Cell · 2025 · PMC11984680 · PMID 39605173

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0755

boldest claim

The sentences

highly significantp < 0.001actually significant

A highly significant relationship between AgeAccelGrim and sex ( T 4,94 = −5.200, p < 0.001) was also expected, given that sex is included in GrimAge calculation (Lu et al., 2019 ).

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a trend toward significancep = 0.0755so close (0.05 < p ≤ 0.1)

There was no significant relationship between global ICI signal fraction ( T 5,93 = 1.353, p = 0.179 n.s.) or global ICA signal fraction ( T 5,93 = −0.298, p = 0.766 n.s.), but there was a trend toward significance with global ECI signal fraction ( T 5,93 = 1.797, p = 0.0755 n.s.) indicating that AgeAccelGrim may be signaling the presence of extracellular water in the aging brain (Figure 5a ). 3.3.

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