Progestin-primed ovarian stimulation (PPOS) in preimplantation genetic testing for aneuploidy: a retrospective study and meta-analysis.

The meta-analysis showed that the biochemical pregnancy rate (OR = 1.07, 95% CI: 0.91–1.25, I 2 = 0%, P = 0.42, 4 studies, 6097 cycles), clinical pregnancy rate (OR = 1.01, 95% CI: 0.87–1.18, I 2 = 0%, P = 0.89, 4 studies, 6097 cycles), ongoing pregnancy rate (OR = 1.12, 95% CI: 0.95–1.31, I 2 = 0%, P = 0.16, 2 studies, 5849 cycles) and live birth rate were similar (OR = 1.06, 95% CI: 0.70–1.60, I 2 = 0%, P = 0.80, 3 studies) between PPOS and GnRH-ant protocols, while the miscarriage rate showed a decreasing trend (OR = 0.67, 95% CI: 0.48–0.93, I 2 = 0%, P = 0.02, 4 studies) (Fig. 3 ).

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