Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition.

Furthermore, our observation that cyclic peptides can be discovered that selectively target only one or a small subset of Gram-negative organisms through BamA inhibition is highly significant given that narrow-spectrum antibiotics are less likely to harm commensal organisms than broad spectrum antibiotics and would therefore reduce the risk of collateral Clostridoides difficile infection and disorders that result from non-specific perturbation of the microbiome.

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