NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model.

Finally, when analyzing REM sleep, we again detected a decrease in the delta power density and an increase in the theta power density in Ts Veh compared with WT Veh at baseline ( Figure 1 D, middle ), with an increase in theta power but a nonsignificant trend toward delta power at recovery ( Figure 1 D, right ).

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We found that Ts Veh mice presented greater motor activity than WT Veh mice did at baseline during the light phase and presented an increasing trend during the dark phase ( Figure 3 B, left ).

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