Revealing the Causal Relationship Between Differential White Blood Cell Counts and Depression: A Bidirectional Two-Sample Mendelian Randomization Study.

Depress Anxiety · 2025 · PMC11987073 · PMID 40225727

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0.0360

closest p · 0.7× alpha

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boldest claim

The sentences

marginal significancep = 0.036actually significant

Furthermore, a marginal significance was noted in the positive correlation between depression and lymphocyte levels (IVW beta = 0.029, p = 0.036, p FDR = 0.071).

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marginally significantp = 0.036actually significant

Results: Reverse MR analysis indicated a causal relationship where depression leads to an increase in overall WBC count (IVW beta = 0.031, p = 0.015, p FDR = 0.044) and specifically in basophil count (IVW beta = 0.038, p = 0.006, p FDR = 0.038), with a marginally significant impact on lymphocyte count (beta = 0.029, p = 0.036, p FDR = 0.071).

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