Impact of increasing CD4 count threshold eligibility for antiretroviral therapy initiation on advanced HIV disease and tuberculosis prevalence and incidence in South Africa: an interrupted time series analysis.

Interrupted time series of new ART initiations from April 2012 to February 2020 From the segmented linear regression and interrupted time series analyses ( table 2A , figure 1A ) , from April 2012 to December 2014, when the initiation CD4 count eligibility was <350 cells/μL, the monthly number of ART initiators was gradually rising, although with weak evidence of an increasing trend (coefficient 16.4, 95% CI −0.8, 33.6).

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The results show a decreasing trend in the proportion of initiators with advanced HIV disease, declining by 1.4% per month (RR 0.986, 95% CI 0.984, 0.988) from April 2012 to December 2014, when the initiation CD4 count eligibility was <350 cells/μL.

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