Among the twelve studies included—nine of which were pooled in meta-analyses—chlorhexidine did not significantly reduce the incidence or severity of mucositis compared to placebo, although a trend toward significance was observed in patients receiving chemotherapy.
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Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.
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However, there was a notable trend toward an increased incidence of ONJ in patients who also received bisphosphonate therapy.