Astrocytic RNA editing regulates the host immune response to alpha-synuclein.

Sci Adv · 2025 · PMC11988446 · PMID 40215316

Europe PMC DOI

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highly significantP value < 2 × 10 −16actually significant

As predicted, αsyn-O treatment generated an increase in the number of editing sites in all cultures (15.8% in astrocyte-only, 26.2% in neuron-only, and 11.1% in astro-neuronal cultures), which was highly significant (chi-squared P value < 2 × 10 −16 for increased exonic proportion in all cases).

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