Berberine Derivative Compound 13 as a Potent Promoter of Osteoblast Differentiation via Akt and PKC Signaling Pathways.

Int J Mol Sci · 2025 · PMC11989097 · PMID 40243591

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a notable trendno p-value reported

A notable trend was observed with the substitution at R 3 ; when OCH 3 was present, as in compound 13 , it led to the highest ALP activity (159.48%), indicating that this specific group played a crucial role in enhancing the interaction with the enzyme.

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