Exploring Clinical and Imaging Differences in COVID-19: an Observational Approach to the IFITM3 rs12252 Polymorphism.

Table 3 and Table 4 present the distribution of patients based on disease severity and sex, as well as disease severity and IFITM3 genotype (homozygous or heterozygous). Considering the assumption that patients with severe symptoms of COVID-19 might be more associated with a heterozygous genotype, the application of a 1-sided Fisher’s Exact Test reveals a tendency toward statistical significance (p=0.072), in the direction of patients with severe symptoms having a higher frequency of heterozygous genotype (16.1%; n=5) in comparison to patients with mild symptoms (0%) ( Figure 4 ).

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