Subclinical iron deficiency is a strong predictor of bacterial vaginosis in early pregnancy.

We found no significant association between iron supplementation (37/98 or 37.8%) and maternal sTfR concentrations (p = 0.95) or with the combined sTfR-ferritin indexes following log transformation (p = 0.20 to 0.97), while there was a marginally significant association between serum ferritin concentrations and supplemental iron intake (p = 0.053).

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In contrast, a highly significant difference between the healthy and vaginosis-like microflora groups of women was shown in mean values of sTfR concentrations (1.15 ± 0.30 mg/L versus 1.37 ± 0.38 mg/L, p = 0.008) and in mean iron deficiency log 10 [sTfR/ferritin] index values (1.57 ± 0.30 versus 1.08 ± 0.56, p = 0.003), indicating a strong association between iron deficiency and vaginosis-like microflora.

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