Comparison of Patent Foramen Ovale Closure vs Medical Therapy for the Prevention of Recurrent Cryptogenic Stroke: A Systematic Review.

J Saudi Heart Assoc · 2025 · PMC11996193 · PMID 40230868

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a slight trendno p-value reported

[ 22 ] noted a slight trend favoring medical therapy in older patients, suggesting that the benefits of closure may diminish with age or in patients with complex comorbidities.

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